About the Program

In 2002, Bayer HealthCare instituted the Bayer Hemophilia Awards Program with the following mission:

The Bayer Hemophilia Awards Program supports basic and clinical research and education in hemophilia. Through grants provided to early career investigators, fellows in training, and other hemophilia care professionals, the program seeks to support the next steps for the next generation of care and treatment options for people with hemophilia worldwide.

Who We Are

The Bayer Group is a global enterprise with core competencies in the fields of health care, nutrition and high-tech materials. Bayer HealthCare, a subgroup of Bayer AG, with annual sales of EUR 16,913 million (2010), is one of the world’s leading, innovative companies in the health care and medical products industry and is based in Leverkusen, Germany. The company combines the global activities of the Animal Health, Consumer Care, Medical Care and Pharmaceuticals divisions. Bayer HealthCare’s aim is to discover and manufacture products that will improve human and animal health worldwide. Bayer HealthCare has a global workforce of 53,400 employees and is represented in more than 100 countries. Find more information at www.bayerhealthcare.com.

Bayer envisions the Hemophilia Awards Program as a step toward making the dream of hemophilia cures and improved treatments a reality.

The Bayer Hemophilia Awards Program demonstrates our commitment to the global bleeding disorders community and to advancing the state of the art of hemophilia care.

Research Priorities

Currently, the Program’s Research Priorities are focused on hemophilia. The program’s research priorities for the 2014/2015 cycle are as follows:

  • Patient-related, e.g. comorbidities, inhibitors, joint disease
  • Treatment-related, e.g. new products, regimens, gene therapy
  • Mechanistic, e.g. molecular mechanisms, experimental models
  • Outcomes research, e.g. patient-reported outcomes, quality of life

Previous Research

In previous award cycles the Program has provided funding to support several projects in the following areas:

  • Aspects of the molecular biology of vWF structure and function and the diagnosis and treatment of vWD
  • The function and regulation of platelets and the diagnosis of platelet disorders.

As a result, the Program will not award projects in these areas during this award cycle.

Excluded Research Topics

In order to maintain a focus on hemophilia and bleeding disorders, the Program will not support research focused on:

  • Products or technologies licensed or patented by competitors of Bayer
  • Cancer diagnosis or therapy
  • AIDS diagnosis or hepatitis therapy except where specifically related to patients with hemophilia and HIV, HCV or HBV
  • Cardiovascular disease diagnosis or therapy
  • Purely thrombotic disorders.

Dates & Deadlines

Thank you for your interest in applying for the Bayer Hemophilia Awards Program. This program represents Bayer’s continuing commitment to taking the next steps for the next generation of people with hemophilia to enjoy a better quality of life and treatment options.

Applications will be processed solely through the Internet and all applications must be submitted in English.

As a first step, applicants should submit a Letter of Intent describing the proposed project in 500 words or fewer. All Letters of Intent submitted will receive an e-mail confirming receipt.

Letters of Intent (LOI) will be reviewed by all 12 members of the Grants Review and Awards Committee. In some cases, additional information may be requested.

Selected applicants will be invited to submit a full proposal that will be reviewed by at least two members of the Grants Review and Awards Committee. These applicants will be e-mailed a full application form.

The results of the review process and funding decisions will be communicated to applicants in May each year. Funded applicants must send a letter of acceptance and enter into an agreement outlining obligations and understandings prior to disbursement of funds.

Awardees will be invited to attend an Awards Dinner that will coincide with the bi-annual meetings of the World Federation of Hemophilia (WFH) or the International Society for Thrombosis and Hemostasis (ISTH).

The table below summarizes the application timelines for 2014/15.

Action Date
LOI submissions Permitted throughout the year
Deadline for LOI consideration November 30, 2014
GRAC reviews LOIs December 2014 / January 2015
GRAC informs applicants January 31, 2015
Applicants develop Full Proposals February/March 2015
Full Proposals submitted March 2015
GRAC reviews Full Proposals April/May 2015
Applicants notified of GRAC decisions May/June 2015
Funding available July/August 2015

Application Process

Letters of Intent and Full Applications are reviewed by the Grants Review and Awards Committee which comprises 12 members, representing many of the leading experts from clinical and academic medicine:

  • Johannes Oldenburg MD, Bonn, Germany (chairman)
  • Marijke van den Berg MD, Utrecht, Netherlands
  • Erik Berntorp MD, Malmö, Sweden
  • Craig Kessler MD, Washington DC, USA
  • David Lillicrap MD, Kingston, Canada
  • Pier Mannucci MD, Milan, Italy
  • Andrea Pritchard Kennedy, PhD, RN, MN, Calgary, AB, Canada
  • Brenda Riske MS, MBA, MPA, Aurora, CO, USA
  • Midori Shima MD, Nara, Japan
  • Alok Srivastava MD, Vellore, India
  • Valder Arruda MD, Philadelphia, USA
  • Gil White MD, Milwaukee, WI, USA

All members of the Grants Review and Awards Committee will review the Letters of Intent and determine which candidates will be invited to submit full applications. Full applications will be reviewed by at least two members of the committee.

Reviewers will evaluate full applications according to the criteria outlined in the Awards section of this website. The reviewers will provide written comments and preliminary numeric scores according to these criteria.

The Committee will meet to discuss individual proposals including strengths, weaknesses and scoring. In this meeting, a consensus score for each grant application will be agreed upon. Proposals will then be ranked according to these scores in order to determine funding. In the event of identical scoring, the Committee will discuss the proposals in question and revise the scoring in order to clearly define a ranked priority. Funding will occur on a regional basis.

Three regions are defined as:

  1. United States and Canada
  2. Europe (for the purposes of this award, the Europe region includes Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom)
  3. Japan, China, India, Australia and all other countries.

Awards will be determined on the final priority score as agreed by the Grants Review and Awards Committee. In the event that inadequate numbers of acceptable applications are received from a particular region, additional acceptable proposals will be funded solely on the basis of priority scores, without regard to region.

The Committee’s decision is final and there is no appeal mechanism. Applicants who have constructive suggestions about the review of their applications, or the process in general, are encouraged to contact us. See Contact.

Conflict of Interest

The Program has ‘conflict of interest’ guidelines that ensure reviews are conducted in a fair and equitable manner. Reviewers will not participate in the review or priority scoring of applications in which they, or institutions with which they are affiliated, have an interest. Also, to the extent practicable, reviewers will not participate in the review of proposals competing for funding with proposals for individuals associated with their institutions.

Confidentiality

The members of the Grants Review and Awards Committee are bound by the confidentiality rules generally applicable to such bodies.

Current Award Recipients: 2014

Fellowship Project Award

Dr Davide Matino Dr Davide Matino
McMaster University, Hamilton, ON, Canada
Potential determinants of ITI success using immune gene expression profiling
Dr Antonino Cannavò Dr Antonino Cannavò
Fondazione Luigi Villa, Milan, Italy
Complete immunological characterization of patients enrolled in the SIPPET study

Early Career Investigator Award

Dr Juan Melero-Martin Dr Juan Melero-Martin
Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
Bioengineering vascular networks for FVIII delivery with iPSC-derived cells from hemophilic patients
Dr Matteo Bovolenta Dr Matteo Bovolenta
University of Ferrara, Ferrara, Italy
Transcriptional enhancement as therapeutic approach of coagulation factors promoter mutations
Dr Lacramioara Ivanciu Dr Lacramioara Ivanciu
The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Factor IX variants for treatment of hemophilia
Dr Suman Sood Dr Suman Sood
University of Michigan, Ann Arbor, MI, USA
Chronic kidney disease in the hemophilia population

Special Project Award

Dr Brian Brown Dr Brian Brown
Mount Sinai School of Medicine, New York, NY, USA
Targeted correction of hemophilia A using CRISPR-mediated editing
Dr Francesca Fallarino Dr Francesca Fallarino
University of Perugia, Perugia, Italy
Resetting tolerance to FVIII via aryl hydrocarbon receptor activation in hemophilia A
Dr Mettine Bos Dr Mettine Bos
Leiden University Medical Center, Leiden, The Netherlands
A novel cofactor-based procoagulant protein as bypassing agent for hemophilia
Dr Jordan Shavit Dr Jordan Shavit
University of Michigan, Ann Arbor, MI, USA
Identification of novel hemostatic bypassing agents using a zebrafish model

Caregiver Award

JoAnn Nilson JoAnn Nilson
Royal University Hospital, Saskatoon, SK, Canada
Implementation and Utilization of an electronic application developed specifically for young men with mild hemophilia
Hannie van Wanroij Hannie van Wanroij
Radboud University Medical Centre, Nijmegen, The Netherlands
Shared medical appointments to change LIfestyles of overweight heMophilia patients (SLIM study)
Dènise Bestetti Dènise Bestetti
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
The effect of hydrotherapy in haemophilic patients after joint replacement of the lower limb
Kuixing Li Kuixing Li
Peking Union Medical College Hospital, Beijing, P.R. China
Caring for carriers in China – development/evaluation of a culturally-relevant bleed assessment tool

Past Award Recipients